Download MicroRNAs in malignant tumors of the skin: First steps of by Michael Sand PDF

By Michael Sand

Michael Sand provides the reader an outline of present thoughts in expression profiling of miRNAs and their maturation equipment within the dermis. This ebook is a postdoctoral thesis on miRNAs in cutaneous malignant cancer and non-melanoma epidermis melanoma with a spotlight at the miRNA processing equipment and miRNA expression profiling. The learn provided during this e-book was once played within the Dermatologic surgical procedure part on the division of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and offers the reader an summary of present innovations in expression profiling of miRNAs and their maturation equipment within the skin.

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Extra info for MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine

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Hsa-miR-146b-5p, overexpressed in this patient collective, shows interactions with twhasolecular-pathologically relevant genes in PCMM. 2 Examinations on malignant melanoma 49 (SMAD4). SMAD4 is an important part of the TGF-beta signal transduction cascade, which demonstrates properties in PCMM that promote the formation of multiple tumors [194]. EGFR was overexpressed in PCMM cell lines and influences the metastasis of PCMM [195]. hsa-miR-26a shows a rhasced expression in the collective. The target gene for hsa-miR-26a is enhancer of zeste homolog 2 (EZH2), a cell cycle-regulating and transcription-limiting gene.

Edu. dmi. org). A total of 16 significantly up-regulated miRNAs (hsa-miR-17, miR18a, hsa-miR-18b, hsa-miR-19b, hsa-miR-19b-1*, hsa-miR-93, hsa-miR106b, hsa-miR-125a-5p, hsa-miR-130a, hsa-miR-181c, hsa-miR-181c*, hsa-miR-181d, hsa-miR-182, hsa-miR-455-3p, hsa-miR-455-5p, and hsa-miR-542-5p) and 10 significantly down-regulated (hsa-miR-29c, hsamiR-29c*, hsa-miR-139-5p, hsa-miR-140-3p, hsa-miR-145, hsa-miR378, hsa-miR-572, hsa-miR-638, hsa-miR-2861 and hsa-miR-3196) were described. The miRNA expression profiles strongly indicated that Oncomir-1 (miRNA cluster hsa-miR-17-92) participates in the pathogenesis of this epithelial skin tumor through the Sonic-Hedgehog signal transduction pathway known from the BCC.

Above the dendrogram, the number of clusters at different positions on the dendrogram is shown. 52 Fig. 3-24: 3 Summary and discussion of this work The successful validation of the miRNA expressiohasrofileshastained hasng the mhasoarray hasulted from a TaqMan qRT-PCR of significantly downhasgulatehashsa-miR-141, hsa-miR-149, hsamiR-20has hsa-miR-204, hsa-miR-455-3p) and significantly upregulated miRNAs (hsa-miR-21, hsa-miR-142-3p, hsa-miR-155, hsa-miR-223, hsa-miR-301a). 4 Closing remarks The discovery of miRNAs and their functions has changed the understanding of the molecular pathology of a number of illnesses [4].

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