By Michael Sand
Michael Sand provides the reader an outline of present thoughts in expression profiling of miRNAs and their maturation equipment within the dermis. This ebook is a postdoctoral thesis on miRNAs in cutaneous malignant cancer and non-melanoma epidermis melanoma with a spotlight at the miRNA processing equipment and miRNA expression profiling. The learn provided during this e-book was once played within the Dermatologic surgical procedure part on the division of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and offers the reader an summary of present innovations in expression profiling of miRNAs and their maturation equipment within the skin.
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Extra info for MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine
Hsa-miR-146b-5p, overexpressed in this patient collective, shows interactions with twhasolecular-pathologically relevant genes in PCMM. 2 Examinations on malignant melanoma 49 (SMAD4). SMAD4 is an important part of the TGF-beta signal transduction cascade, which demonstrates properties in PCMM that promote the formation of multiple tumors . EGFR was overexpressed in PCMM cell lines and influences the metastasis of PCMM . hsa-miR-26a shows a rhasced expression in the collective. The target gene for hsa-miR-26a is enhancer of zeste homolog 2 (EZH2), a cell cycle-regulating and transcription-limiting gene.
Edu. dmi. org). A total of 16 significantly up-regulated miRNAs (hsa-miR-17, miR18a, hsa-miR-18b, hsa-miR-19b, hsa-miR-19b-1*, hsa-miR-93, hsa-miR106b, hsa-miR-125a-5p, hsa-miR-130a, hsa-miR-181c, hsa-miR-181c*, hsa-miR-181d, hsa-miR-182, hsa-miR-455-3p, hsa-miR-455-5p, and hsa-miR-542-5p) and 10 significantly down-regulated (hsa-miR-29c, hsamiR-29c*, hsa-miR-139-5p, hsa-miR-140-3p, hsa-miR-145, hsa-miR378, hsa-miR-572, hsa-miR-638, hsa-miR-2861 and hsa-miR-3196) were described. The miRNA expression profiles strongly indicated that Oncomir-1 (miRNA cluster hsa-miR-17-92) participates in the pathogenesis of this epithelial skin tumor through the Sonic-Hedgehog signal transduction pathway known from the BCC.
Above the dendrogram, the number of clusters at different positions on the dendrogram is shown. 52 Fig. 3-24: 3 Summary and discussion of this work The successful validation of the miRNA expressiohasrofileshastained hasng the mhasoarray hasulted from a TaqMan qRT-PCR of significantly downhasgulatehashsa-miR-141, hsa-miR-149, hsamiR-20has hsa-miR-204, hsa-miR-455-3p) and significantly upregulated miRNAs (hsa-miR-21, hsa-miR-142-3p, hsa-miR-155, hsa-miR-223, hsa-miR-301a). 4 Closing remarks The discovery of miRNAs and their functions has changed the understanding of the molecular pathology of a number of illnesses .