By Harry M. Meyer Jr. M.D. (auth.), John C. Petricciani, Hope E. Hopps, Paul J. Chapple (eds.)
This quantity stems from a symposium subsidized by way of the W. Alton Jones mobilephone technological know-how heart, Lake Placid long island. the second one Annual W. Alton Jones mobile technological know-how middle Symposium: cellphone Substrates and Their Use within the creation of Vaccines and different Biologicals was once held October 23-26, 1978. the guts is an operational unit of the Tissue tradition organization and provides, in collaboration with the Association's schooling Committee, a variety of academic and study actions. up to now twenty years there were quite a few nationwide and foreign meetings with regards to cellphone cultures used to provide organic items. these principally handled the know-how and linked matters that have been present on the time of the conferences. for instance, as human diploid cells have been constructed and proposed to be used in vaccine construction, a couple of conferences have been held to check the professionals and cons of human diploid cells. a large number of facts was once supplied at these meetings which shaped the foundation for the eventual attractiveness of that mobile procedure. each one assembly extra to the final base of information within the quarter of cellphone cultures and their program to the present and novel set of difficulties encountered. mostly, the individuals reaffirmed the elemental premises that have been formulated within the early days of polio virus vaccine construction in regards to the standards for acceptability of cells whilst utilized in the manufacture of biologics meant for humans.
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Extra info for Cell Substrates: Their Use in the Production of Vaccines and Other Biologicals
Low frequency virus release, low frequency recombinations, selective pressures, and a somewhat higher frequency of variant cell formation provide some very early, even primative basis for quantitating cells as substrates for viral vaccines. By comparing the relative risks of these events with an even lower liklihood of all these events coming together in a human population, it seems unlikely they would be of detectable clinical significance. Nevertheless, issues concerning cell substrates or even general principles concerning cell substrates are at an early developmental stage.
Figure 2d) is broadly similar to what has been observed (5, 7, 8). Detailed comparison of the theoretical and experimental results is hampered at present by the limited realism of our assumption that committed cells do not divide more slowly as they approach death. We are currently working towards modification of the theoretical model to acco~modate a more realistic form of this assumption. This will alter the shape of the right-hand end of the profile in Figure 2d. VARIATION IN CULTURE LIFESPA~ So far, we have taken no account of the stochastic nature of the process of dilution and loss of the uncommitted cells.
Jacobs, un9ublished observations). Indeed a growth experiment performed using MRC-5 fibroblasts (13) by one of us (RH) some years ago gives a close fit to the model's 9rediction (10). HETEROGE~EITY \VITHI~ CELL POPULATIO~S Wi th each generation, cells transfer from one subclass of the 90pulation to another. An ever-diminishing pool of uncommitted T. B. L. KIRKWOOD AND R. HOLLIDAY 40 a Infinite growth b Finite growth en CD Z :::; AD = c:o c:o z c:o :; ... " , '" lost by dilution a.. a.. " ... ", 1 M CELL &ENERATlDNS Figure I Alternative cell culture growth curves predicted by the commitment theory of cellular aging for an initially fully uncommitted cell population.