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3 B ter 14 Figure 1. 2. 2. The arrow indicates the orientation 5' -> 3' of the loci, and the gene group order in the loci. The length of the arrow is proportional to the total size of the loci, indicated in kilobases (kb). The total number of genes in the TRA and TRD loci is shown between parentheses. The number of functional genes defines the potential TRA repertoire which comprises 95-97 genes (40-41 TRAV, 4-5 TRAV/DV, 50 TRAJ, and 1 TRAC) per haploid genome. The five genes, designated as TRAV/DV, have been found rearranged to J genes of the TRA locus, and to D and J genes of the TRD locus, and can therefore be used in the synthesis of alpha or delta chains'^.

The five genes, designated as TRAV/DV, have been found rearranged to J genes of the TRA locus, and to D and J genes of the TRD locus, and can therefore be used in the synthesis of alpha or delta chains'^. 2 spans 1000 kilobases (kb) (Fig. 2). It consists of 54 TRAV genes belonging to 41 subgroups^*, 61 TRAJ genes localized on 71 kb^-^^, and a unique TRAC gene^^-^^ ^he most 5' TRAV genes occupy the most centromeric position, whereas the TRAC gene, 3' of the locus, is the most telomeric gene in the TRA locus.

1988)) Eur. J. Immunol. 18, 789-794. 33 Triebel, F. and Hercend, T. (1989) Immunol. Today 10, 186-188. 34 Band, H. et al. (1987) Science 238, 682-684. 35 Borst, J. et al. (1988) J. Exp. Med. 167, 1625-1644. 36 Ciccone, E. et al. (1988) J. Exp. Med. 168, 1-11. J. et al. (1988) J. Immunol. 141, 1476-1479. A. et al. (1995) J. Immunol. 155, 3060-3067. 39 Kabelitz, D. et al. (1994) J. Immunol. 152, 3128-3136. 40 Hinz, T. et al. (1997) Int. Immunol. 9, 1065-1072. 4^ Kabelitz, D. (1999) Microbes and Infection 1, 255-261.

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