Download Brain Hypothermia: Pathology, Pharmacology, and Treatment of by Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D. PDF

By Nariyuki Hayashi (auth.), Nariyuki Hayashi M.D., Ph.D. (eds.)

Rapid growth in know-how and its software to analysis and tracking of mind tissue temperature and metabolism have ended in advances within the remedy for severely brain-injured sufferers and breakthroughs in figuring out the pathophysiology of mind harm. the most recent thought of mind hypothermia remedy clarifies pursuits reminiscent of mind thermal pooling, protecting mind hypoxia linked to catecholamine surge, the metabolic shift from glucose to lipids, and selective radical harm of dopamine within the imperative frightened approach. This quantity explains the mechanism of mind harm and the way mind hypothermia remedy differs from different hypothermia treatment in 4 significant sections: mind harm Mechanism, Pathophysiology of Hypothermia, uncomplicated learn of Hypothermia therapy, and medical stories of mind Hypothermia. The publication is a invaluable resource for practitioners and researchers in neurosurgery and neurology and in severe care and emergency medicine.

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Additional info for Brain Hypothermia: Pathology, Pharmacology, and Treatment of Severe Brain Injury

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During the following 24h, a marked proliferation of microglia (more than 5 times higher than those in 24-h slices) was observed in normothermic (37°C) animals. At 72h after compression a large number of the proliferated microglia were still seen in normothermic animals, but no increase was observed in hypothermic animals. In slices from normothermic animals at 48 and 72 h after injury, most of the proliferated microglia were positive to OX-42 staining (data not shown), which recog- 50 T. Ogata et al.

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